1Vinitharan,V. 1Balakumar,S.
1Arasasratnam,V. 2Muhunthan, K.
1Department of Biochemistry 2Department
of Obstetrics & Gynecology, Faculty of Medicine, University of Jaffna, Sri
Lanka.
Abstract
Various
definitions of metabolic syndrome have been proposed by several organizations.
The aim of this study was to analyze the variations in the metabolic syndrome
prevalence using three proposed definitions and to
compare the degree to which participants were being similarly or differently
classified by the three definitions. . The prevalence of metabolic
syndrome was studied in 395 Tamils in Jaffna, Sri Lanka. The International
Diabetic Federation (IDF) definition, National Cholesterol Education Program
Adult Treatment Panel III (NCEP ATP III) definition and the definition
introduced by five organizations in an attempt to create a “unified definition” were used for analysis. The agreement and disparity in the diagnosis of the metabolic syndrome between these definitions were analyzed. According to IDF, ATPIII and the unified definitions, total prevalence of metabolic syndrome was 27.6%, 18.0%, and 32.2%, respectively. 14.9% (IDF), 11.94% (ATPIII) and 23.13% (Unified definition) of the male participants and 34.10% (IDF), 21.07% (ATPIII) and 36.78% (Unified definition) of female participants were classified as having the metabolic syndrome according to the definition used. The prevalence of the metabolic syndrome was high in the female assessed by any one of the three proposed criteria. Among the people who have metabolic syndrome, 51% in female, 29% in male were classified as having metabolic syndrome under all three definitions. Among the participants who were classified as having the metabolic syndrome using the any of the three criteria, 99.0% of male, 87.1% of female met at least two of the three definitions. The recently introduced unified definition covers all subjects who were classified as having metabolic syndrome by other two definitions. Prevalence was elevated on applying the unified definition: 4.6% (Vs. IDF) and 14.2% (Vs. ATPIII). Increased prevalence of metabolic syndrome reported by unified criteria compared to the IDF criteria was due to the fact that waist circumference was not considered as the compulsory indicator. The prevalence was lowered in ATPIII criteria due to its elevated cutoff levels for fasting blood sugar and waist circumference. Conclusion: The prevalence of the metabolic syndrome was high in this population assessed by any one of the three proposed criteria. The unified definition has a good agreement with other two definitions for the metabolic syndrome in the identification of subjects with the syndrome. Unified definition can be considered as a universal definition in future. We insist on using the unified definition for future researches.
introduced by five organizations in an attempt to create a “unified definition” were used for analysis. The agreement and disparity in the diagnosis of the metabolic syndrome between these definitions were analyzed. According to IDF, ATPIII and the unified definitions, total prevalence of metabolic syndrome was 27.6%, 18.0%, and 32.2%, respectively. 14.9% (IDF), 11.94% (ATPIII) and 23.13% (Unified definition) of the male participants and 34.10% (IDF), 21.07% (ATPIII) and 36.78% (Unified definition) of female participants were classified as having the metabolic syndrome according to the definition used. The prevalence of the metabolic syndrome was high in the female assessed by any one of the three proposed criteria. Among the people who have metabolic syndrome, 51% in female, 29% in male were classified as having metabolic syndrome under all three definitions. Among the participants who were classified as having the metabolic syndrome using the any of the three criteria, 99.0% of male, 87.1% of female met at least two of the three definitions. The recently introduced unified definition covers all subjects who were classified as having metabolic syndrome by other two definitions. Prevalence was elevated on applying the unified definition: 4.6% (Vs. IDF) and 14.2% (Vs. ATPIII). Increased prevalence of metabolic syndrome reported by unified criteria compared to the IDF criteria was due to the fact that waist circumference was not considered as the compulsory indicator. The prevalence was lowered in ATPIII criteria due to its elevated cutoff levels for fasting blood sugar and waist circumference. Conclusion: The prevalence of the metabolic syndrome was high in this population assessed by any one of the three proposed criteria. The unified definition has a good agreement with other two definitions for the metabolic syndrome in the identification of subjects with the syndrome. Unified definition can be considered as a universal definition in future. We insist on using the unified definition for future researches.
Key words: Metabolic syndrome, IDF, ATPIII, Unified definition
Source: Jaffna Science Association - Abstracts of Research papers - Volume 19
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